sparsentan will reduce the level or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and cuts down efficacy connected to these substrates. itraconazole will raise the degree or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://modafinil78999.win-blog.com/5727394/not-known-details-about-modafinil