Topical Treatments Around-The-Counter Medicine Around-the-counter creams and ointments, Particularly the ones that include capsaicin, an extract derived from chili peppers, may be applied topically on the knee to help you decrease pain by reducing the depth of pain signals sent together nerve pathways. Opioid Pain Relievers Opioid medications like oxycodone, https://www.theorthopaedicandpainpractice.com/understanding-and-treating-elderly-knee-pain/