Health risks from obesity and excess weight 1. Insulin Resistance The biggest health risk from excess weight (read, fat) is insulin resistance. As fat begins to surround the visceral organs, like the liver and pancreas, it compromises their functionality, leading to inadequate insulin or insulin that the body is resistant to. As a result, glucose in the bloodstream is unable to ente... https://www.freedomfromdiabetes.org/blog/post/it's-all-about-weight-loss-ffd/2784