Tapentadol is partly metabolized from the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medications that enhance or repress the activity/expression of one or more of those enzymes, as well as with substrates of these enzymes (on account of competition for the enzyme); some enzyme mediators/substrates https://henryb931txt3.wikicarrier.com/user